Name: Glucose, Liquid
CAS No: Liquid glucose.
BP: Liquid Glucose PhEur: Glucose, Liquid USP-NF: Liquid Glucose
Corn syrup; C*PharmSweet; Flolys; Glucomalt; glucose syrup; glucosum liquidum; Glucosweet; Mylose; Roclys; starch syrup.
Liquid glucose.
Liquid glucose is used as a base in oral solutions and syrups and also as a granulating and coating agent in tablet manufacture. In sugar solutions for tablet coating, liquid glucose is used to retard the crystallization of the sucrose. Liquid glucose is also used in confectionery products. See Table I.
Liquid glucose is an aqueous solution of several compounds, principally dextrose, dextrin, fructose, and maltose, with other oligosaccharides and polysaccharides. It is a colorless, odorless, and viscous sweet-tasting liquid, ranging in color from colorless to straw-colored. Liquid glucose is classified into four categories according to its degree of hydrolysis, expressed as dextrose equivalent (DE): Type I: 20–38 DE; Type II: 38–58 DE; Type III: 58–73 DE; Type IV: >73 DE.
See Table II.
Density 1.43 g/cm3 at 208C Solubility Miscible with water; partially miscible with ethanol (90%). Viscosity (dynamic) 13.0–14.5 mPa s (13.0–14.5 cP) at 218C.
Liquid glucose should be stored in a well-closed container in a cool, dry place. Elevated temperatures will cause discoloration.
Incompatible with strong oxidizing agents.
Liquid glucose is prepared by the incomplete acidic or enzymatic hydrolysis of starch.
Liquid glucose is used in oral pharmaceutical formulations and confectionery products and is generally regarded as a nontoxic and nonirritant material. It may be consumed by diabetics. See also Dextrose. LD50 (mouse, IV): 9 g/kg(1)
Observe normal precautions appropriate to the circumstances and quantity of material handled.
GRAS listed. Included in the FDA Inactive Ingredients Database (oral solutions, syrups, and tablets; topical emulsions and gels). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Dextrin; dextrose; maltose.
A specification for glucose syrup is contained in the Food Chemicals Codex (FCC).(2) The PhEur 6.4 also includes a specification for glucose, liquid, spray-dried. The EINECS number for glucose is 200-075-1.