Name: Sodium Formaldehyde Sulfoxylate
CAS No: Sodium formaldehyde sulfoxylate [149-44-0], Sodium formaldehyde sulfoxylate dihydrate [6035-47-8]
USP-NF: Sodium Formaldehyde Sulfoxylate
Formaldehyde hydrosulfite; formaldehyde sodium sulfoxylate; formaldehydesulfoxylic acid sodium salt; methanesulfinic acid, hydroxy-, monosodium salt; monosodium hydroxymethane sulfinate; Rongalite; sodium hydroxymethane sulfinate; sodium hydroxymethylsulfinate; sodium methanalsulfoxylate; sodium sulfinomethanolate.
Sodium formaldehyde sulfoxylate [149-44-0], Sodium formaldehyde sulfoxylate dihydrate [6035-47-8]
CH3NaO3S 118.09 CH3NaO3S2H2O 154.11
Sodium formaldehyde sulfoxylate is a water-soluble antioxidant and is generally used as the dihydrate. It is used in the formulation of injection products at a level of up to 0.1% w/v in the final preparation administered to the patient.
When freshly prepared, sodium formaldehyde sulfoxylate occurs as white, odorless crystals, which quickly develop a characteristic garlic odor on standing.
See Table I.
Acidity/alkalinity pH = 9.5–10.5 (2% w/v aqueous solution) Melting point 64–688C (dihydrate) Solubility Freely soluble in water; slightly soluble in ethanol, chloroform, ether and benzene.
Store in well-closed, light-resistant containers at controlled room temperature (15–308C).
Sodium formaldehyde sulfoxylate is incompatible with strong oxidizing agents; it is decomposed by dilute acid.
Sodium formaldehyde sulfoxylate is manufactured from sodium dithionate and formaldehyde in water.
The toxicological properties of sodium formaldehyde sulfoxylate have not been fully investigated. However, it is used in the formulation of injection products at a level to 0.1% w/v in the final preparation administered to the patient. Sodium formaldehyde sulfoxylate is moderately toxic by ingestion, and when heated to decomposition it emits toxic fumes of sulfur dioxide and sodium oxide.(1) LD50 (mouse, oral): 4 g/kg(1,2) LD50 (rat, IP): >2 g/kg(2) LD50 (rat, oral): >2 g/kg(2
Observe normal precautions appropriate to the circumstances and quantity of the material handled. May cause irritation of the eyes, skin, respiratory tract and digestive tract; the use of eye protection, a respirator and gloves is strongly recommended.
Included in the FDA Inactive Ingredients Database (parenteral products up to 0.1% via the IM, IV, and SC routes). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Zinc formaldehyde sulfoxylate. Zinc formaldehyde sulfoxylate Empirical formula C2H6O6S2Zn Molecular weight 256.5 CAS number [24887-06-7] Comments Used as an additive in polymers and textiles. The EINECS number is 246-515-6.
Sodium formaldehyde sulfoxylate has been investigated as an antidote to mercury poisoning, but is considered less effective than dimercaprol (British anti-lewisite (BAL)) and other treatments.(3,4) It is also used as an industrial bleach. It is used in chemical synthesis as a nucleophilic agent in the preparation of sulfones. The empirical formula and molecular weight are also given as CH4O3SNa and 119.1, respectively.(1) The EINECS number for sodium formaldehyde sulfoxylate is 205-739-4. The PubChem Compound ID for sodium formaldehyde sulfoxylate is 23725019.